IntegrinSignalingPathway
Integrins are cell surface receptors that interact with the extracellular matrix and mediate intracellular signals in response to the extracellular matrix including cellular shape, mobility, and progression through the cell cycle. Integrins do not themselves possess a kinase domain or enzymatic activity but rely on association with other signaling molecules to transmit signals. Interactions between the extracellular ......閱讀全文
Stat3－Signaling－Pathway
STATs, Signal Transducers and Activators of Transcription, are transcription factors that are phosphorylated by JAK kinases in response to cytokine ac
Chaperones－modulate－interferon－Signaling－Pathway
Signaling by interferon-gamma stimulates anti-viral responses and tumor suppression through the heterodimeric interferon-gamma receptor. Signaling is
T－Cell－Receptor－Signaling－Pathway
The T Cell Receptor plays a key role in the immune system. The specificity of the receptor is governed by the binding site formed from the mature alph
OX40－Signaling－Pathway
Two key features of the immune system are the clonal expansion of B cells and T cells in response to antigens, and the potentiation of future immune r
Rho－cell－motility－signaling－pathway
RhoA is a small G-protein in the Rho family that regulates cell morphology via actin cytoskeleton reorganization in response to extracellular signals.
IGF1－Signaling－Pathway
Insulin like growth factor 1 (IGF-1) and its receptor (IGF-1R) provide a potent proliferative signaling system that stimulates growth in many differen
Bioactive－Peptide－Induced－Signaling－Pathway
Many different peptides act as signaling molecules, including the proinflammatory peptide bradykinin, the protease enzyme thrombin, and the blood pres
p53－Signaling－Pathway
p53 is a transcription factor who's activity is regulated by phosphorylation. The function is p53 is to keep the cell from progressing through the
Msp/Ron－Receptor－Signaling－Pathway
MSP, macrophage-stimulating protein, acts through the transmembrane receptor kinase RON (Stk in mice) to play a role in inflammation and the response
TNFR1－Signaling－Pathway
TNFR1 (a.k.a. p55, CD120a) is the receptor for TNF(alpha) and also will bind TNF(beta). Upon binding TNF(alpha) a TNFR1+ cell is triggered to undergo
NFkB－Signaling－Pathway
Nuclear factor kB (NF-kB) is a nuclear transcription factor that regulates expression of a large number of genes that are critical for the regulation
TNFR2－Signaling－Pathway
TNFR2 is the receptor for the 171 amino acid 19 kD TNF(beta) (a.k.a. lymphotoxin). TNF(beta) is produced by activated lymphocytes and can be cytotoxic
CXCR4－Signaling－Pathway
CXCR4 is a chemokine receptor in the GPCR gene family, and is expressed by cells in the immune system and the central nervous system. In response to b
SODD/TNFR1－Signaling－Pathway
The tumor necrosis factor (TNF) receptor superfamily contains several members with homologous cytoplasmic domains known as death domains (DD). The int
FAS－signaling－pathway－(－CD95－)
Receptors in the TNF receptor family are associated with the induction of apoptosis, as well as inflammatory signaling. The Fas receptor (CD95) mediat
p38－MAPK－Signaling－Pathway
p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are deli
CD40L－Signaling－Pathway
The CD40 receptor was first associated with expression in B cells and the role it plays through its ligand CD40L (CD154) in moderating T cell activati
D4GDI－Signaling－Pathway
D4-GDI (GDP dissociation inhibitor) is a negative regulator of the ras related Rho Family of GTPases. Since the rho GTPases promote cytoskeletal and m
Rac－1－cell－motility－signaling－pathway
Rac-1 is a small G-protein in the Rho family that regulates cell motility in response to extracellular signals. Several changes in cytoskeletal struct
Signaling－Pathway－from－GProtein－Families
G-aS-coupled receptors stimulate adenylyl cyclase (AC), which synthesizes cAMP from ATP. In contrast Gai-coupled receptors inhibit AC and so reduce cA
Aspirin－Blocks－Signaling－Pathway－Involved－in－Platelet－Activation
Activation of the protease-activated GPCRs in platelets contributes to platelet activation in clotting. The protease-activated receptors PAR1 and PAR4
IL22－Soluble－Receptor－Signaling－Pathway
IL-22 is an inflammatory cytokine related to IL-10 that is produced by T cells and that induces a response in cells through a heterodimeric cell surfa
IL10－Antiinflammatory－Signaling－Pathway
IL-10 is a cytokine with potent anti-inflammatory properties, repressing the expression of inflammatory cytokines such as TNF-alpha, IL-6 and IL-1 by
gSecretase－mediated－ErbB4－Signaling－Pathway
The HER4/erbB4 receptor tyrosine kinase is a member of the EGF1 receptor family. HER4 is a receptor for the neuregulins (NRGs), a family of growth and
Erk1/Erk2－Mapk－Signaling－pathway
The p44/42 MAP Kinase pathway consists of a protein kinase cascade linking growth and differentiation signals with transcription in the nucleus. Growt
PTEN－dependent－cell－cycle－arrest－and－apoptosis
PTEN is a tumor suppressor gene. Recombinant PTEN is capable of dephosphorylating phosphatidylinositol 3,4,5-triphosphate[PI(3,4,5)P3], the product of
IL12－and－Stat4－Dependent－Signaling－Pathway－in－Th1－Development
Interleukin-12 (IL-12) promotes cell-mediated immunity by inducing Th1 cell differentiation and activation of both T cells and NK cells. Dendritic cel
GPB7基因編碼功能及結構描述
這個基因的產物屬于一個小的轉接器蛋白家族，已知它與許多受體酪氨酸激酶和信號分子相互作用。該基因編碼一種與表皮生長因子受體（EGFR）和腎上腺素受體相互作用的生長因子受體結合蛋白該蛋白通過與粘著斑激酶（FAK）結合在整合素信號通路和細胞遷移中發揮作用已經發現了編碼兩種不同亞型的轉錄變體[由RefSeq
GRB7基因編碼功能及結構描述
這個基因的產物屬于一個小的轉接器蛋白家族，已知它與許多受體酪氨酸激酶和信號分子相互作用。該基因編碼一種與表皮生長因子受體（EGFR）和腎上腺素受體相互作用的生長因子受體結合蛋白該蛋白通過與粘著斑激酶（FAK）結合在整合素信號通路和細胞遷移中發揮作用已經發現了編碼兩種不同亞型的轉錄變體[由RefSeq
GPB7基因突變與藥物因子介紹
這個基因的產物屬于一個小的轉接器蛋白家族，已知它與許多受體酪氨酸激酶和信號分子相互作用。該基因編碼一種與表皮生長因子受體（EGFR）和腎上腺素受體相互作用的生長因子受體結合蛋白該蛋白通過與粘著斑激酶（FAK）結合在整合素信號通路和細胞遷移中發揮作用已經發現了編碼兩種不同亞型的轉錄變體[由RefSeq