這個基因編碼酪氨酸蛋白激酶家族的一個成員。編碼蛋白通過內皮受體酪氨酸激酶tie2抑制血管生成素1信號傳導，在血管生成和血管穩定性中發揮重要作用。編碼蛋白的外區裂解解除了對Tie2的抑制，并由多種因素介導，包括血管內皮生長因子另外，已經觀察到該基因編碼多個亞型的剪接轉錄變體[由RefSeq提供，2011年11月]
This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]