該基因編碼dna依賴性蛋白激酶（dna-pk）的催化亞單位。與ku70/ku80異二聚體蛋白共同參與dna雙鏈斷裂修復和重組。編碼的蛋白質是PI3/PI4激酶家族的成員。
This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.