這個基因編碼一種蛋白質,可能在前mrna剪接中起作用。染色體易位(X;1)(p11;q21)導致該基因與TFE3(基因id 7030)融合,與乳頭狀腎細胞癌有關PRCC-TFE3融合蛋白在癌組織中表達,可能與基因反式激活改變有關這種融合蛋白也與細胞周期的破壞有關。
This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle.