該基因編碼的蛋白是ser/thr蛋白磷酸酶pp2c家族的成員。pp2c家族成員是細胞應激反應途徑的負調控因子。該基因的表達在不同的環境脅迫下以p53依賴的方式誘導。在腫瘤抑制蛋白tp53/p53誘導下，這種磷酸酶負性調節p38-map激酶mapk/p38的活性，從而降低p53的磷酸化，進而抑制p53介導的轉錄和凋亡。因此，這種磷酸酶介導p38-p53信號的反饋調節，有助于生長抑制和抑制應激誘導的凋亡。該基因位于已知在乳腺癌中被擴增的染色體區域。在乳腺癌細胞系和原發性乳腺腫瘤中都檢測到該基因的擴增，這表明該基因在乳腺癌的發生發展中起著一定的作用。
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.