這個基因編碼類固醇甲狀腺激素視黃醇受體超家族的一個成員編碼的蛋白質可以作為轉錄因子該基因突變與多巴胺能功能障礙相關的疾病有關，包括帕金森病、精神分裂癥和躁狂抑郁癥該基因的失調可能與類風濕關節炎有關已經描述了選擇性剪接的轉錄變體，但其生物學有效性尚未確定。
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]