由該基因編碼的蛋白質具有一個c-末端結構域，其trna 3&；8242；處理內核糖核酸酶活性，從而催化從前體trnas中去除3'拖車。該蛋白還與激活的smad家族成員2（smad2）及其核伴侶forkhead box h1（又稱fast-1）相互作用，減少表達可抑制轉化生長因子β誘導的生長停滯。這個基因的突變會增加患前列腺癌的風險。已發現該基因編碼不同亞型的多個轉錄變體。[由RefSeq提供，2009年9月]
The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]