該基因編碼DNA聚合酶δ的125kDa催化亞單位。DNA聚合酶三角洲既具有聚合酶活性，又具有3-5'外切酶活性，在DNA復制和修復中起著關鍵作用。另外還觀察到該基因的剪接轉錄變體，該基因的假基因位于6號染色體的長臂上。
This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6.